Anti-Human FGFR1 Recombinant Antibody (FR1-H7)
CAT#: TAB-052WM
Antibody FR1-H7 binds FGFR-1(IIIb) and -1(IIIc) with strong affinities, but does not recognize any of the other FGFRs. Results from kinetic analysis indicated the antibody binds to FGFR-1b and -1c equally well. The KDs of the interactions were determined to be approximately 50 μM for both receptors. This product can be potentially used for antagonizing EGFR-1 or EGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
Tested Data
Gene Expression
WB
Figure 1 Anti-FGFR1 Therapeutic Antibody (FR1-H7) (TAB-052WM) in Western Blot
WB analysis of TAB-052WM (left) and negative control (no TAB-052WM incubation, right)
Lane 1: Non-reducing condition
Lane 2: Reducing condition
Antigen: Recombinant Human FGFR1 Protein (His Tag)
ELISA
Figure 2 Anti-FGFR1 Therapeutic Antibody (FR1-H7) (TAB-052WM) in ELISA
ELISA analysis of TAB-052WM was performed by coating with Recombinant Human FGFR1 Protein (His Tag).
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Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/33614/67230_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077782-FGFR1
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Specifications
- Host Species
- Human
- Derivation
- Phage-displayed human Fab library
- Type
- Human Antibody
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- FR1-H7
- Applications
- ELISA, Neut
- Related Disease
- Obesity, diabetes
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
- Gene ID
- 2260
- UniProt ID
- P11362
REVIEWS AND Q&AS
CITATIONS
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Adaptable apps
This antibody exhibits exceptional adaptability and maintains performance quality across a variety of assays.
Perfect for targets with low abundance
Low-abundance proteins in samples were successfully identified. This antibody's sensitivity has changed the game.
Improved blocking efficiency
When blocking steps were completed correctly, the antibody produced clear findings. efficient against background problems in different experimental configurations.
Q&As
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What negative effects might freeze-thaw cycles have on this antibody?
A: Reduced activity and denaturation of antibodies can result from repeated freeze-thaw cycles. Using an alias can help avoid this.
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What variables might impact the antibody's performance in my tests?
A: Antibody concentration, incubation period, temperature, and sample quality are among the variables. For optimal effects, maximize each.
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In what way should my assay handle non-specific binding?
A: To lessen non-specific interactions, tighten up the wash processes, improve the blocking environment, and further dilute the antibody.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-052WM, RRID: AB_3111778)
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone FR1-H7"
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1638z | Mouse Anti-FGFR1 Recombinant Antibody (clone 20H8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0118-FY | Human Anti-FGFR1 Recombinant Antibody (HPAB-0118-FY) | ELISA | Human IgG1 |
| MRO-0578-CN | Rabbit Anti-FGFR1 Recombinant Antibody (clone CBACN-225) | WB, IF | Rabbit IgG |
| HPAB-3044LY | Mouse Anti-FGFR1 Recombinant Antibody (HPAB-3044LY) | ELISA | Mouse IgG |
| VS3-XY704 | Mouse Anti-FGFR1 Recombinant Antibody (clone 3D4F7) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-283CL | Human Anti-FGFR1 Recombinant Antibody (TAB-283CL) | WB, IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-053WM | Mouse Anti-FGFR1 Recombinant Antibody (TAB-053WM) | WB, FC | Mouse IgG |
| TAB-053WM-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-053WM-S(P)) | WB | Mouse scFv |
| TAB-053WM-F(E) | Mouse Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-053WM-F(E)) | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-054WM | Human Anti-FGFR1 Recombinant Antibody (TAB-054WM) | ELISA | Human IgG |
| TAB-052WM-S(P) | Anti-Human FGFR1 Recombinant Antibody scFv Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (TAB-054WM-S(P)) | ELISA | Human scFv |
| TAB-052WM-F(E) | Anti-Human FGFR1 Recombinant Antibody Fab Fragment (FR1-H7) | ELISA, BL, Neut | Human Antibody |
| TAB-054WM-F(E) | Human Anti-FGFR1 Recombinant Antibody; Fab Fragment (TAB-054WM-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-825CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL537) | WB, Neut | Mouse IgG1 |
| NEUT-826CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone MM0277-6F10) | WB, Neut | Mouse IgG1 |
| NEUT-827CQ | Mouse Anti-FGFR1 Recombinant Antibody (clone CBL059) | Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1296 | Hi-Affi™ Rabbit Anti-FGFR1 Recombinant Antibody (clone DS1296AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0118-FY-S(P) | Human Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-0118-FY-S(P)) | ELISA | Human scFv |
| HPAB-N0346-YC-S(P) | Human Anti-FGFR1 Recombinant Antibody scFv Fragment (HPAB-N0346-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0485LY-S(P) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); scFv Fragment | ELISA | Human scFv |
| HPAB-0701-FY-F(E) | Human Anti-FGFR1 Recombinant Antibody Fab Fragment (HPAB-0701-FY-F(E)) | ELISA | Human Fab |
| HPAB-3044LY-S(P) | Mouse Anti-FGFR1 Recombinant Antibody; scFv Fragment (HPAB-3044LY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0485LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A7/C6/D9); Fab Fragment | ELISA | Human Fab |
| HPAB-0486LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-A9/H10); Fab Fragment | ELISA | Human Fab |
| HPAB-0487LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-B1/E12); Fab Fragment | ELISA | Human Fab |
| HPAB-0488LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-C1); Fab Fragment | ELISA | Human Fab |
| HPAB-0489LY-F(E) | Human Anti-FGFR1 Recombinant Antibody (clone 121-R3P1-C7); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY35 | Human Anti-FGFR1 (clone FR1-H7) scFv-Fc Chimera | ELISA, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC333 | Recombinant Anti-FGFR1 Vesicular Antibody, EV Displayed (VS-0425-YC333) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2538 | Anti-FGFR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2539 | Anti-Mouse FGFR1 Immunohistochemistry Kit | IHC |
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